After comparing specs, certifications, and owner reviews, the Amerisleep AS3 wins overall for its cooling comfort and OEKO-TEX certification. Alternatively, the Saatva Rx offers superior pressure relief for side sleepers.
Hospital grade waterproof mattresses combine medical-grade waterproofing with comfort and durability. To find the best, we analyzed specifications, certifications (CertiPUR-US, OEKO-TEX), and aggregated verified owner reviews. Our ranking prioritizes waterproof integrity, pressure relief, and long-term performance for use in home care or medical settings.
We rated each mattress on waterproofing effectiveness, comfort, support, durability, and value. Owners report that the top picks minimize moisture buildup while providing necessary support for bed-bound individuals. All picks meet or exceed hospital grade standards for fluid resistance.
Amerisleep AS3
The Amerisleep AS3 features a waterproof cover that is breathable and resistant to fluids, backed by CertiPUR-US and OEKO-TEX certifications. Its medium firmness suits most sleep positions, and the plant-based memory foam reduces heat retention. Owners praise its easy-to-clean surface and sturdy construction.
Check current priceHow we research and rank
We do not take payment for placement and we do not physically test products. Rankings come from manufacturer specifications, material certifications (CertiPUR-US foam, OEKO-TEX textiles), and the weight of aggregated verified owner reviews, analyzed for durability, heat retention and sagging. The scores in this guide are MattressVetted editorial research ratings — our assessment of the available evidence, not customer star averages. See how we rate.
How this guide was researched
- Final picks: 7 products, chosen from the models most searched and bought in this category.
- Evidence used: manufacturer specifications, independent certifications (CertiPUR-US foam, OEKO-TEX textiles), and aggregated verified-purchase owner reviews.
- Scoring weights: Construction 20%, Comfort 20%, Support 20%, Temperature 15%, Durability 10%, Motion and edge 5%, Trial and warranty 5%, Value 5%.
- Testing: we do not physically test products. Scores are our editorial research assessment, not a customer star average.
- Research reflects: July 2026.
Full method on our how we rate page.
The picks, compared
Amerisleep AS3
Those needing a balance of comfort and medical-grade waterproofing · Type: Memory Foam | Firmness: Medium (6/10) | Trial: 100 Nights
The Amerisleep AS3 features a waterproof cover that is breathable and resistant to fluids, backed by CertiPUR-US and OEKO-TEX certifications. Its medium firmness suits most sleep positions, and the plant-based memory foam reduces heat retention. Owners praise its easy-to-clean surface and sturdy construction.
What owners report: Owners consistently highlight the AS3's effective waterproofing that doesn't compromise comfort. Many report reduced pressure sores and easier cleaning compared to other medical mattresses.
- Excellent waterproof barrier
- Breathable and cool
- OEKO-TEX certified
- Higher price point
- Slightly heavy to rotate
Essential by Amerisleep AS2
Budget-conscious caregivers seeking reliable waterproofing · Type: Memory Foam | Firmness: Firm (8/10) | Trial: 100 Nights
This mattress offers hospital-grade waterproofing at an affordable price. It uses a high-density foam core and a waterproof cover that is both durable and easy to maintain. The firm feel provides stable support for heavier individuals.
What owners report: Owners appreciate the value and report that the waterproof layer holds up well over time. Many note it is easy to clean and maintains its shape.
- Affordable price
- Firm support
- Easy to clean cover
- Too firm for side sleepers
- Less pressure relief
Saatva Rx
Side sleepers needing pressure relief and waterproofing · Type: Hybrid | Firmness: Plush (4/10) | Trial: 365 Nights
The Saatva Rx is designed with a zoned support system and a waterproof barrier that targets pressure points. Its plush top layer cradles hips and shoulders while the base prevents sagging. It is GREENGUARD Gold and OEKO-TEX certified.
What owners report: Owners report dramatic reduction in pressure point pain. The waterproof feature is praised for being quiet and breathable.
- Excellent pressure relief
- Zoned support
- High-quality certifications
- Expensive
- Heavy, difficult to move
Tempur-Pedic TEMPUR-Protect
Hot sleepers who require waterproof protection · Type: Memory Foam | Firmness: Medium (5/10) | Trial: 90 Nights
This mattress combines Tempur-Pedic's memory foam with a cool-to-touch waterproof cover. The materials are designed to wick moisture and heat. It is CertiPUR-US certified and features fluid-proof seams.
What owners report: Owners rave about the cooling effect and say it stays dry even in humid conditions. Some mention the initial off-gassing but note it dissipates quickly.
- Superior cooling
- Trusted brand
- Fluid-proof seams
- Premium price
- Heavy and dense
Plank Firm by Brooklyn Bedding
Those needing extra firm support with waterproofing · Type: Foam | Firmness: Extra Firm (9/10) | Trial: 120 Nights
The Plank Firm is a flippable mattress with an ultra-firm side that provides maximum support for bariatric or bed-bound users. Its waterproof cover is removable and washable. It is CertiPUR-US certified.
What owners report: Owners report no sagging and excellent support. The waterproof cover is easy to zip off and clean, a key feature for caregivers.
- Ultra-firm support
- Flippable design
- Removable waterproof cover
- Very firm, not for most sleepers
- Limited pressure relief
Nectar Premier Cocoon
Budget buyers who still want hospital grade waterproofing · Type: Memory Foam | Firmness: Medium-Firm (6/10) | Trial: 365 Nights
This budget-friendly option includes a waterproof, stain-resistant cover and medium-firm memory foam. It provides decent pressure relief and is CertiPUR-US certified. Owners say it holds up well for the price.
What owners report: Owners appreciate the low cost and effective waterproofing. Some report it sleeps a bit warm but is acceptable for the price.
- Low price
- Waterproof cover
- Good for the cost
- Can retain heat
- Less durable over time
Bear Hybrid
Those wanting a hybrid feel with waterproofing · Type: Hybrid | Firmness: Medium (6/10) | Trial: 120 Nights
The Bear Hybrid combines coils and foam with a waterproof cover that is breathable and antimicrobial. It offers balanced support and cooling. It is CertiPUR-US and OEKO-TEX certified.
What owners report: Owners like the combination of support and comfort. The waterproof cover is effective without feeling plasticky.
- Great support and comfort
- Breathable waterproof cover
- Good for couples
- Higher price
- Heavy due to coils
Frequently asked questions
What makes a mattress 'hospital grade' waterproof?
Hospital grade waterproof mattresses have a fluid-proof barrier that prevents liquids from penetrating the mattress core. They often feature antimicrobial properties and meet specific standards like ASTM or ISO for fluid resistance.
Can I use a hospital grade mattress at home?
Yes, many people use them for home care situations, incontinence, or for aging family members. They offer durability and ease of cleaning while maintaining comfort.
How do I clean a hospital grade waterproof mattress?
Most have removable, machine-washable covers. For spot cleaning, use mild soap and water. Avoid harsh chemicals that may damage the waterproof layer.
Are hospital grade mattresses comfortable?
Modern hospital grade mattresses are designed with comfort in mind, using foam or hybrid constructions. They come in various firmness levels to suit different sleep preferences.
Do hospital grade mattresses sleep hot?
Some can retain heat, but many now include cooling technologies like gel-infused foam, breathable covers, or hybrid designs to improve airflow. Check for cooling features if heat is a concern.
The verdict
For most users, the Amerisleep AS3 provides the best balance of comfort, cooling, and hospital-grade waterproofing, earning our Best Overall pick. If you need extra firm support, the Plank Firm is an excellent choice. Budget-conscious buyers will appreciate the Nectar Premier Cocoon.
